IHEP OpenIR  > 院士  > 期刊论文
Cu-64 Radiopharmaceutical Chemistry
Ma L(马磊); 刘宇(多); Chai ZF(柴之芳); Ma, L; Liu, Y; Chai, ZF
刊名PROGRESS IN CHEMISTRY
2012
卷号24期号:9页码:1720-1728
关键词radiopharmaceutical Cu-64 ligands
学科分类Chemistry
英文摘要Copper-64, as a radionuclide, can be simultaneously used for both imaging and potential therapy, because of its specific nuclear characteristics, such as the half-life (12. 7 h) and decay properties (beta(+), 0. 653 MeV, 17. 8%; beta(-), 0. 579 MeV, 38. 4%). In the past two decades, with the well-established copper coordination chemistry, more and more novel ligands for copper-64 have been designed and synthesized, like DOTA, TETA, NOTA, CB-TE2A, C3B-DO2A, etc. Nowadays, copper-64 is able to bind not only with biologically relevant small molecules, but also with some antibodies, proteins, and nanoparticles. From another point of view, the stability of the copper-64-labeled radiopharmaceuticals has been significantly improved in both vitro and vivo tests. Thus, the exploration of novel ligands and receptors with new labeling strategies has become a hot issue in the copper radiopharmaceutical chemistry. Up to now, many new copper-64-labeled radiopharmaceuticals have been synthesized, some of which exhibit excellent biodistributions, as Cu-64-ATSM is an effective radiopharmaceutical in imaging of hypoxic tissues and Cu-64-PTSM is a good blood flow tracer, etc. This paper will selectively review some new labeling methods for copper-64-labeled radiopharmaceuticals, and some potential applications of these coordination compounds in both imaging and therapy. The perspectives of this field is addressed as well.
收录类别SCI
WOS记录号WOS:000309485800010
引用统计
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224165
专题院士_期刊论文
推荐引用方式
GB/T 7714
Ma L,Liu Y,Chai ZF,et al. Cu-64 Radiopharmaceutical Chemistry[J]. PROGRESS IN CHEMISTRY,2012,24(9):1720-1728.
APA 马磊,刘宇,柴之芳,Ma, L,Liu, Y,&Chai, ZF.(2012).Cu-64 Radiopharmaceutical Chemistry.PROGRESS IN CHEMISTRY,24(9),1720-1728.
MLA 马磊,et al."Cu-64 Radiopharmaceutical Chemistry".PROGRESS IN CHEMISTRY 24.9(2012):1720-1728.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
6748.pdf(382KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[马磊]的文章
[刘宇(多)]的文章
[柴之芳]的文章
百度学术
百度学术中相似的文章
[马磊]的文章
[刘宇(多)]的文章
[柴之芳]的文章
必应学术
必应学术中相似的文章
[马磊]的文章
[刘宇(多)]的文章
[柴之芳]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 6748.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。