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Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
Xu, Q; Liu, YX; Su, SS; Li, W; Chen, CY; Wu, Y; 李炜(多
2012
发表期刊BIOMATERIALS
卷号33期号:5页码:1627-1639
摘要Targeted delivery strategies are becoming increasingly important. Herein, a novel hyperbranched amphiphilic poly[(amine-ester)-co-(D,L-lactide)]/1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer (HPAE-co-PLA/DPPE) with RGD peptide (cRGDfK) and transferrin (If) on the periphery was synthesized and used to prepare paclitaxel-loaded nanoparticles (NPs) for dual-targeting chemotherapy. These NPs show satisfactory size distribution, high encapsulated efficiency and a pH-dependent release profile. The intrinsic fluorescence of the hyperbranched copolymer renders the detection and tracking of NPs in vitro and in vivo conveniently. In vitro cytotoxicity studies proved that the presence of cRGDfK enhanced the cytotoxic efficiency by 10 folds in delta(v)beta(3) integrin over-expressed human umbilical vein endothelial cells, while If improved cytotoxicity by 2 folds in If receptor over-expressed human cervical carcinoma cells. The drug-loaded NPs can be efficiently transported into the vascular endothelial cells and the target tumor cells. These results indicate that the cRGDfK and If decorated HPAE-co-PLA/DPPE could deliver chemotherapies specifically inside the cell via receptor-mediated endocytosis with greater efficacy. Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy. (C) 2011 Elsevier Ltd. All rights reserved.
关键词Hyperbranched copolymer nanoparticle Tumor-targeting cRGDfK Transferrin Intrinsic fluorescence Controlled drug release
学科领域Engineering; Materials Science
DOI10.1016/j.biomaterials.2011.11.012
收录类别SCI
WOS记录号WOS:000300474000042
引用统计
被引频次:105[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224158
专题多学科研究中心
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GB/T 7714
Xu, Q,Liu, YX,Su, SS,et al. Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles[J]. BIOMATERIALS,2012,33(5):1627-1639.
APA Xu, Q.,Liu, YX.,Su, SS.,Li, W.,Chen, CY.,...&李炜.(2012).Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.BIOMATERIALS,33(5),1627-1639.
MLA Xu, Q,et al."Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles".BIOMATERIALS 33.5(2012):1627-1639.
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