Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents
He R(何睿); Xing GM(邢更妹); He, R; Xing, GM; Wang, XX; Jiao, YH; Zhao, H; Yuan, H; Wang, SK; Dong, JQ; Lei, H;; Yuan H(袁慧); Wang SK(王术宽); Dong JQ(董金泉)
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2013
卷号13期号:2页码:1549-1554
关键词Metallofullerene Bingel-Hirsch Reaction Paramagnetic Contrast Agent Relaxivity
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.5993
英文摘要Water-soluble malonate multiadducts of paramagnetic gadolinium endohedral metallofullerene, Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8), were synthesized by Bingel-Hirsch reaction. Gd@C-82 was firstly reacted with diethyl bromomalonate in the presence of alkali metal hydride to produce malonic ester multiadducted derivatives, Gd@C-82[C(OOCH2CH3)(2)](x) (x = 3-8), by Bingel reaction. They were isolated and purified to obtain Gd@C-82[C(COOCH2CH3)(2)](6) and Gd@C-82[C(COOCH2CH3)(2)](8) by silica-gel column chromatography with a gradient elution method, which were subsequently hydrolyzed to yield water-soluble Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8) by Hirsch reaction. The structures of the derivatives were characterized by Fourier transform infrared spectrometry and matrix assisted laser desorption ionization time-of-flight mass spectrometry. The longitudinal relaxivities of Gd@C-82[C(COOH)(2)](8) and Gd@C-82[C(COOH)(2)](6), in buffer solution, were found to be 18.20 and 11.08 mM(-1) s(-1) concentration range between 0.001-0.025 mM Gd, and to be 12.71 and 6.73 mM(-1) s(-1) between 0.050-0.200 mM Gd, respectively. The results showed that the measured relaxivities for malonate derivatives of Gd@C-82 were dependent on the concentration of these solutions and the number of hydrophilic carboxyl groups appended on the surface of the Gd@C-82 cage.
收录类别SCI
WOS记录号WOS:000318254500176
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224150
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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He R,Xing GM,He, R,et al. Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(2):1549-1554.
APA 何睿.,邢更妹.,He, R.,Xing, GM.,Wang, XX.,...&董金泉.(2013).Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(2),1549-1554.
MLA 何睿,et al."Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.2(2013):1549-1554.
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