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Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level
Zuo, GH; Kang, SG; Xiu, P; Zhao, YL; Zhou, RH; Zhao YL(赵宇亮)
2013
发表期刊SMALL
卷号9期号:9-10 SI页码:1546-1556
摘要The widespread application of nanomaterials has spurred an interest in the study of interactions between nanoparticles and proteins due to the biosafety concerns of these nanomaterials. In this review, a summary is presented of some of the recent studies on this important subject, especially on the interactions of proteins with carbon nanotubes (CNTs) and metallofullerenols. Two potential molecular mechanisms have been proposed for CNTs' inhibition of protein functions. The driving forces of CNTs' adsorption onto proteins are found to be mainly hydrophobic interactions and the so-called stacking between CNTs' carbon rings and proteins' aromatic residues. However, there is also recent evidence showing that endohedral metallofullerenol Gd@C82(OH)22 can be used to inhibit tumor growth, thus acting as a potential nanomedicine. These recent findings have provided a better understanding of nanotoxicity at the molecular level and also suggested therapeutic potential by using nanoparticles' cytotoxicity against cancer cells.
关键词nanotoxicology proteinnanoparticle interactions molecular simulations carbon nanotubes
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1002/smll.201201381
收录类别SCI
WOS记录号WOS:000319076000011
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被引频次:71[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224149
专题多学科研究中心
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GB/T 7714
Zuo, GH,Kang, SG,Xiu, P,et al. Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level[J]. SMALL,2013,9(9-10 SI):1546-1556.
APA Zuo, GH,Kang, SG,Xiu, P,Zhao, YL,Zhou, RH,&赵宇亮.(2013).Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level.SMALL,9(9-10 SI),1546-1556.
MLA Zuo, GH,et al."Interactions Between Proteins and Carbon-Based Nanoparticles: Exploring the Origin of Nanotoxicity at the Molecular Level".SMALL 9.9-10 SI(2013):1546-1556.
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