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Quantifying and Imaging Engineered Nanomaterials In Vivo: Challenges and Techniques
He X(何潇); Ma YH(马宇辉); Li M(李萌); He, X; Ma, YH; Li, M; Zhang, P; Li, YY; Zhang, ZY;; 张鹏(多); Li YY(李媛媛); Zhang ZY(张智勇)
Source PublicationSMALL
Volume9Issue:9-10 SIPages:1482-1491
AbstractQuantifying and imaging the engineered nanomaterials (ENMs) in vivo can provide information on the bio-distribution and fate of ENMs in living systems. A necessary amount of in vivo quantitative data is indispensable to verify the extrapolation from in vitro tests, to modify the predictive models of ENM exposure, and to underpin the risk management strategy for ENMs. However, it remains a challenge to quantitatively assess the bio-distribution of ENMs under realistic exposure, their long-term deposition (especially in non-targeted tissues), their passage across the natural barriers, and the impacts of nanobio interactions on their in vivo behaviors. Some commonly used techniques for in vivo ENM quantification, such as electron microscopy, fluorescence-based detection, atomic spectroscopy, radiotracing, and techniques basing on synchrotron radiation are reviewed, and their technical characteristics, the state of the art, limitations, and future prospects are addressed.
Keywordengineered nanomaterials quantitative techniques nanotoxicology in vivo studies
Subject AreaChemistry; Science & Technology - Other Topics; Materials Science; Physics
Indexed BySCI
WOS IDWOS:000319076000006
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Document Type期刊论文
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GB/T 7714
He X,Ma YH,Li M,et al. Quantifying and Imaging Engineered Nanomaterials In Vivo: Challenges and Techniques[J]. SMALL,2013,9(9-10 SI):1482-1491.
APA 何潇.,马宇辉.,李萌.,He, X.,Ma, YH.,...&张智勇.(2013).Quantifying and Imaging Engineered Nanomaterials In Vivo: Challenges and Techniques.SMALL,9(9-10 SI),1482-1491.
MLA 何潇,et al."Quantifying and Imaging Engineered Nanomaterials In Vivo: Challenges and Techniques".SMALL 9.9-10 SI(2013):1482-1491.
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