Comparative Bio-Effects of SiO2/Gd2O3 Nanoparticles Depending on Their Core-Shell Structures
Zhang MY(张铭倚); Zhang, MY; Gu ZJ(谷战军); Xing GM(邢更妹); Xia, L; Gu, ZJ; Xing, GM
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2013
卷号13期号:2页码:1270-1273
关键词SiO2/Gd2O3 DNA Damaging Core-Shell Structure RAW 264.7
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1166/jnn.2013.5951
英文摘要Engineered nanoparticles (NPs) can produce negative impacts on human health even in low doses. In this study, Gd2O3 nanoparticles were synthesized via the polyol route and coated with silicon to form particles with different sizes. Although all the SiO2/Gd2O3 NPs did not induce obvious cell death at 10 mu g/mL on a macrophage-like cell line (RAW 264.7), their DNA damaging effects, which is measured by single cell gel electrophoresis (SCGE), is prominent in cells treated with the sample with an overall size of 120 nm. Besides, the NPs with core size of 20 nm induced greater damaging effect than NPs with similar total size but core size of 50 nm. Further test applying the modified SCGE with endonuclease III indicated that the DNA damaging effect was greatly associated with oxide pyridine after the treatment. Using immunoblotting, we found that p53 protein is activated and accumulated after the damage occurred. These results provide a new insight into the adverse effect of nanoparticles with core-shell structures, that not only the overall size but the core size of the particles determines their effect in cells.
收录类别SCI
WOS记录号WOS:000318254500113
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224124
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Zhang MY,Zhang, MY,Gu ZJ,et al. Comparative Bio-Effects of SiO2/Gd2O3 Nanoparticles Depending on Their Core-Shell Structures[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(2):1270-1273.
APA 张铭倚.,Zhang, MY.,谷战军.,邢更妹.,Xia, L.,...&Xing, GM.(2013).Comparative Bio-Effects of SiO2/Gd2O3 Nanoparticles Depending on Their Core-Shell Structures.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(2),1270-1273.
MLA 张铭倚,et al."Comparative Bio-Effects of SiO2/Gd2O3 Nanoparticles Depending on Their Core-Shell Structures".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.2(2013):1270-1273.
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