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Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
Yang, KN; Cao, WP; Hao, XH; Xue, X; Zhao, J; Liu, J; Zhao, YL; Meng, J; Sun, BY; Zhang, JC; Liang, XJ; Zhao YL(赵宇亮); Sun BY(孙宝云)
2013
发表期刊NANOSCALE
卷号5期号:3页码:1205-1212
摘要Although endohedral metallofullerenol [Gd@C-82(OH)(22)](n) nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these nanoparticles act in bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that [Gd@C-82(OH)(22)](n) nanoparticles facilitated the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C-82(OH)(22)](n) nanoparticle treatment. Mechanistically, the effect of [Gd@C-82(OH)(22)](n) nanoparticles on ALP activity was inhibited by the addition of noggin as an inhibitor of the BMP signaling pathway. Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C-82(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis.
学科领域Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c2nr33575a
收录类别SCI
WOS记录号WOS:000313803000051
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224116
专题多学科研究中心
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GB/T 7714
Yang, KN,Cao, WP,Hao, XH,et al. Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway[J]. NANOSCALE,2013,5(3):1205-1212.
APA Yang, KN.,Cao, WP.,Hao, XH.,Xue, X.,Zhao, J.,...&孙宝云.(2013).Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway.NANOSCALE,5(3),1205-1212.
MLA Yang, KN,et al."Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway".NANOSCALE 5.3(2013):1205-1212.
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