Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
Yang, KN; Cao, WP; Hao, XH; Xue, X; Zhao, J; Liu, J; Zhao, YL; Meng, J; Sun, BY; Zhang, JC; Liang, XJ; Zhao YL(赵宇亮); Sun BY(孙宝云)
刊名NANOSCALE
2013
卷号5期号:3页码:1205-1212
学科分类Chemistry; Science & Technology - Other Topics; Materials Science; Physics
DOI10.1039/c2nr33575a
英文摘要Although endohedral metallofullerenol [Gd@C-82(OH)(22)](n) nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these nanoparticles act in bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that [Gd@C-82(OH)(22)](n) nanoparticles facilitated the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C-82(OH)(22)](n) nanoparticle treatment. Mechanistically, the effect of [Gd@C-82(OH)(22)](n) nanoparticles on ALP activity was inhibited by the addition of noggin as an inhibitor of the BMP signaling pathway. Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C-82(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis.
收录类别SCI
WOS记录号WOS:000313803000051
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224116
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
推荐引用方式
GB/T 7714
Yang, KN,Cao, WP,Hao, XH,et al. Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway[J]. NANOSCALE,2013,5(3):1205-1212.
APA Yang, KN.,Cao, WP.,Hao, XH.,Xue, X.,Zhao, J.,...&孙宝云.(2013).Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway.NANOSCALE,5(3),1205-1212.
MLA Yang, KN,et al."Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway".NANOSCALE 5.3(2013):1205-1212.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
6311.pdf(538KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, KN]的文章
[Cao, WP]的文章
[Hao, XH]的文章
百度学术
百度学术中相似的文章
[Yang, KN]的文章
[Cao, WP]的文章
[Hao, XH]的文章
必应学术
必应学术中相似的文章
[Yang, KN]的文章
[Cao, WP]的文章
[Hao, XH]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 6311.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。