The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6
Zhang H(张衡); Gao ZQ(高增强); Wang WJ(王文佳); Zhang, H; Gao, ZQ; Wang, WJ; Liu, GF; Shtykova, EV; Xu, JH; Li, LF; Su, XD; Dong, YH; Liu GF(刘广峰); Xu JH(徐建华); Dong YH(董宇辉)
刊名FEBS LETTERS
2012
卷号586期号:8页码:1147-1153
关键词MPN domain JAMM motif COP9 signalosome CSN6 Crystal structure
学科分类Biochemistry & Molecular Biology; Biophysics; Cell Biology
DOI10.1016/j.febslet.2012.03.029
英文摘要The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5 angstrom crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease. Structured summary of protein interactions: CSN6 and CSN6 bind by x-ray crystallography (View interaction) CSN6 and CSN6 bind by x ray scattering (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
收录类别SCI
WOS记录号WOS:000303106100010
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224110
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Zhang H,Gao ZQ,Wang WJ,et al. The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6[J]. FEBS LETTERS,2012,586(8):1147-1153.
APA 张衡.,高增强.,王文佳.,Zhang, H.,Gao, ZQ.,...&董宇辉.(2012).The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.FEBS LETTERS,586(8),1147-1153.
MLA 张衡,et al."The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6".FEBS LETTERS 586.8(2012):1147-1153.
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