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Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease
Wang HJ(王华建); Wang M(王萌); Wang B(汪冰); Wang, HJ; Wang, M; Wang, B; Li, M; Chen, HQ; Yu, XH; Yang, K; Chai, ZF; Zhao, YL; Feng, WY; Li M(李明); Chen HQ(陈汉青); Chai ZF(柴之芳); Zhao YL(赵宇亮); Feng WY(丰伟悦)
刊名METALLOMICS
2012
卷号4期号:10页码:1113-1118
学科分类Biochemistry & Molecular Biology
DOI10.1039/c2mt20056b
英文摘要The mechanism that triggers amyloid-beta (A beta) fibrillation and aggregation is still elusive. Evidence suggests that the extensional interactions of the amyloid precursor protein (APP) and A beta with transition biometals, copper (Cu) and zinc (Zn), may be key occurrences in the processes of A beta aggregation and toxicity. By using an immunogold labeling technique combined with synchrotron radiation X-ray fluorescence microprobe (SR-mu XRF) scanning analysis, the profiles of APP, A beta 42 and Cu, Zn in the brain of APP transgenic mouse with the development of the disease were characterized. This investigation provides visual, kinetic and spatial evidence of the correlation of APP and A beta-metals in AD brain sections. The visual evidence demonstrates the association of metals Cu and Zn with A beta 42 during plaque formation, which helps implicate the role of metal ion homeostasis in human AD pathology.
收录类别SCI
WOS记录号WOS:000310123100012
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224106
专题院士_期刊论文
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_多学科研究中心
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Wang HJ,Wang M,Wang B,et al. Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease[J]. METALLOMICS,2012,4(10):1113-1118.
APA 王华建.,王萌.,汪冰.,Wang, HJ.,Wang, M.,...&丰伟悦.(2012).Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease.METALLOMICS,4(10),1113-1118.
MLA 王华建,et al."Immunogold labeling and X-ray fluorescence microscopy reveal enrichment ratios of Cu and Zn, metabolism of APP and amyloid-beta plaque formation in a mouse model of Alzheimer's disease".METALLOMICS 4.10(2012):1113-1118.
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