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Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex
Li, MJ; Lan, TY; Lin, ZS; Yi, CQ; Chen, GN
2013
发表期刊JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
卷号18期号:8页码:993-1003
摘要A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV-vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects.
关键词Copper(II) complex DNA binding Cytotoxicity Nucleolytic cleavage
学科领域Biochemistry & Molecular Biology; Chemistry
DOI10.1007/s00775-013-1048-7
收录类别SCI
WOS记录号WOS:000327406000012
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224090
专题多学科研究中心
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GB/T 7714
Li, MJ,Lan, TY,Lin, ZS,et al. Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2013,18(8):993-1003.
APA Li, MJ,Lan, TY,Lin, ZS,Yi, CQ,&Chen, GN.(2013).Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,18(8),993-1003.
MLA Li, MJ,et al."Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 18.8(2013):993-1003.
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