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Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging
Zhou LJ(周亮君); Gu ZJ(谷战军); Liu XX(刘潇潇); Zhou, LJ; Gu, ZJ; Liu, XX; Yin, WY; Tian, G; Yan, L; Jin, S; Ren, WL; Xing, GM; Li, W; Chang, XL; Hu, ZB; Zhao, YL; Yin WY(尹文艳); Tian G(田甘); Yan L(晏亮); Jin S(金珊); Ren WL(任文璐); Xing GM(邢更妹); Li W(李炜); Chang XL(常雪灵); Zhao YL(赵宇亮)
2012
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
Volume22Issue:3Pages:966-974
AbstractLanthanide (Ln(3+)) doped Gd2O3 nanoparticles (NPs) have been prepared via a thermal treatment of gadolinium carbonate precursor, which was obtained by simple hydrothermal treatment of Gd(NO3)(3) solution in the presence of urea and glycerol. The size of the nanoparticles could be fine tuned from 270 to 10 nm by varying the amount of glycerol, which acted as a chelating agent to control the size of the nanoparticles. Calcination of the gadolinium carbonate nanoparticles at 500 degrees C led to the formation of uniform Gd2O3 nanoparticles without any obvious morphology change. By doping the lanthanide ions (Yb, Er/Tm) into the Gd2O3 host matrix, these nanoparticles emitted strong upconversion (UC) fluorescence under 980 nm near infrared (NIR) excitation. Moreover, their emission colors could be tuned by simply changing either the co-dopant concentration or the dopant species. Water dispersibility was achieved by forming a silica layer on the surface of the Gd2O3 nanoparticles. The possibility of using these silica-coated upconversion nanoparticles for optical imaging in vitro/in vivo has been demonstrated. It was also shown that these Gd2O3 nanoparticles brightened the T-1-weighted images and enhanced r(1) relaxivity of water protons, which suggested they act as T-1 contrast agents for magnetic resonance (MR) imaging. Thus, Gd2O3 nanoparticles doped with Ln(3+) ions provide the dual modality of optical and magnetic resonance imaging.
Subject AreaChemistry; Materials Science
DOI10.1039/c1jm13758a
Indexed BySCI
WOS IDWOS:000299212700027
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/224086
Collection多学科研究中心
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GB/T 7714
Zhou LJ,Gu ZJ,Liu XX,et al. Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY,2012,22(3):966-974.
APA 周亮君.,谷战军.,刘潇潇.,Zhou, LJ.,Gu, ZJ.,...&赵宇亮.(2012).Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging.JOURNAL OF MATERIALS CHEMISTRY,22(3),966-974.
MLA 周亮君,et al."Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging".JOURNAL OF MATERIALS CHEMISTRY 22.3(2012):966-974.
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