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Interactions between U(VI) and bovine serum albumin
Yang, Y; Feng YX(冯一潇); Feng, YX; Wang, YF; Wang, L; Shi, WQ; Wang L(王琳); Shi WQ(石伟群)
2013
发表期刊JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
卷号298期号:2页码:903-908
摘要Interest in bio-toxicology of uranium resulting from its radioactive heavy metal property has been growing enormously in recent years. The interactions between uranium(VI) [U(VI)] and bovine serum albumin (BSA) at physiological pH were studied by spectroscopic methods. Fuorescence results revealed the formation of BSA-U(VI) complex, the binding constants as well as the number of binding sites were determined. In particular, the effects of U(VI) binding on the secondary structures of BSA were examined by means of Fourier transformation infrared spectroscopy equipped with attenuated total reflection (FT-IR/ATR). It was found that the alpha-helix component of BSA decreased gradually with increasing concentration of U(VI). In contrast, the beta-sheets, turns, and random coil structures all increased correspondingly. Our work would shed light on the possible interaction mechanism between U(VI) and proteins in aqueous solutions.
关键词Uranium BSA Secondary structure FT-IR/ATR
学科领域Chemistry; Nuclear Science & Technology
DOI10.1007/s10967-013-2487-x
收录类别SCI
WOS记录号WOS:000325624300021
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224079
专题多学科研究中心
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GB/T 7714
Yang, Y,Feng YX,Feng, YX,et al. Interactions between U(VI) and bovine serum albumin[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2013,298(2):903-908.
APA Yang, Y.,冯一潇.,Feng, YX.,Wang, YF.,Wang, L.,...&石伟群.(2013).Interactions between U(VI) and bovine serum albumin.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,298(2),903-908.
MLA Yang, Y,et al."Interactions between U(VI) and bovine serum albumin".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 298.2(2013):903-908.
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