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Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice
Xue, YY; Zhang, SS; Huang, YM; Zhang, T; Liu, XR; Hu, YY; Zhang, ZY; Tang, M;张智勇
2012
发表期刊JOURNAL OF APPLIED TOXICOLOGY
卷号32期号:11页码:890-899
摘要This study evaluated the acute toxicity and biokinetics of intravenously administered silver nanoparticles (AgNPs) in mice. Mice were exposed to different dosages of AgNPs (7.5, 30 or 120?mg kg-1). Toxic effects were assessed via general behavior, serum biochemical parameters and histopathological observation of the mice. Biokinetics and tissue distribution of AgNPs were evaluated at a dose of 120?mg kg-1 in both male and female mice. Inductively coupled plasmamass spectrometry (ICP-MS) was used to determine silver concentrations in blood and tissue samples collected at predetermined time intervals. After 2?weeks, AgNPs exerted no obvious acute toxicity in the mice. However, inflammatory reactions in lung and liver cells were induced in mice treated at the 120?mg kg-1 dose level. The highest silver levels were observed in the spleen, followed by liver, lungs and kidneys. The elimination half-lives and clearance of AgNPs were 15.6?h and 1.0?ml h-1 g-1 for male mice and 29.9?h and 0.8?ml h-1 g-1 for female mice. These results indicated that AgNPs could be distributed extensively to various tissues in the body, but primarily in the spleen and liver. Furthermore, there appears to be gender-related differences in the biokinetic profiles in blood and distribution in lungs and kidneys following an intravenous injection of AgNPs. The data from this study provides information on toxicity and biodistribution of AgNPs following intravenous administration in mice, which represents the worst case scenario of toxicity among all the different administration routes, and may shed light in the future use of products containing AgNPs in humans. Copyright (c) 2012 John Wiley & Sons, Ltd.
关键词silver nanoparticles acute toxic effects gender-related biokinetics tissue distribution mice
学科领域Toxicology
DOI10.1002/jat.2742
收录类别SCI
WOS记录号WOS:000309190200003
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224076
专题多学科研究中心
推荐引用方式
GB/T 7714
Xue, YY,Zhang, SS,Huang, YM,et al. Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice[J]. JOURNAL OF APPLIED TOXICOLOGY,2012,32(11):890-899.
APA Xue, YY.,Zhang, SS.,Huang, YM.,Zhang, T.,Liu, XR.,...&Tang, M;张智勇.(2012).Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice.JOURNAL OF APPLIED TOXICOLOGY,32(11),890-899.
MLA Xue, YY,et al."Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice".JOURNAL OF APPLIED TOXICOLOGY 32.11(2012):890-899.
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