Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate
Zhu, MT; Nie, GJ; Meng, H; Xia, T; Nel, A; Zhao, YL;赵宇亮
刊名ACCOUNTS OF CHEMICAL RESEARCH
2013
卷号46期号:3页码:622-631
学科分类Chemistry
DOI10.1021/ar300031y
英文摘要Although a growing number of innovations have emerged in the fields of nanobiotechnology and nanomedicine, new engineered nanomaterials (ENMs) with novel physicochemical properties are posing novel challenges to understand the full spectrum of interactions at the nano-bio interface. Because these could include potentially hazardous interactions, researchers need a comprehensive understanding of toxicological properties of nanomaterials and their safer design. In depth research is needed to understand how nanomaterial properties influence bioavailability, transport, fate, cellular uptake, and catalysis of injurious biological responses. Toxicity of ENMs differ with their size and surface properties, and those connections hold true across a spectrum of in vitro to in vivo nano-bio interfaces. In addition, the in vitro results provide a basis for modeling the biokinetics and in vivo behavior of ENMs. Nonetheless, we must use caution in interpreting in vitro toxicity results too literally because of dosimetry differences between in vitro and in vivo systems as well the increased complexity of an in vivo environment. In this Account, we describe the impact of ENM physicochemical properties on cellular bioprocessing based on the research performed in our groups. Organic, inorganic, and hybrid ENMs can be produced in various sizes, shapes and surface modifications and a range of tunable compositions that can be dynamically modified under different biological and environmental conditions. Accordingly, we cover how ENM chemical properties such as hydrophobicity and hydrophilidty, material composition, surface functionalization and charge, dispersal state, and adsorption of proteins on the surface determine ENM cellular uptake, intracellular biotransformation, and bioelimination versus bioaccumulation. We review how physical properties such as size, aspect ratio, and surface area of ENMs influence the interactions of these materials with biological systems, thereby affecting their hazard potential. We discuss our actual experimental findings and show how these properties can be tuned to control the uptake, biotransformation, fate, and hazard of ENMs. This Account provides specific information about ENM biological behavior and safety issues. This research also assists the development of safer nanotherapeutics and guides the design of new materials that can execute novel functions at the nano-bio interface.
收录类别SCI
WOS记录号WOS:000317317200003
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被引频次:156[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224028
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Zhu, MT,Nie, GJ,Meng, H,et al. Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate[J]. ACCOUNTS OF CHEMICAL RESEARCH,2013,46(3):622-631.
APA Zhu, MT,Nie, GJ,Meng, H,Xia, T,Nel, A,&Zhao, YL;赵宇亮.(2013).Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate.ACCOUNTS OF CHEMICAL RESEARCH,46(3),622-631.
MLA Zhu, MT,et al."Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate".ACCOUNTS OF CHEMICAL RESEARCH 46.3(2013):622-631.
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