Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study
Yin, Y; Jin, CF; Eyler, LT; Jin, H; Hu, XL; Duan, L; Zheng, HR; Feng, B; Huang, XY; Shan, BC; Gong, QY; Li, LJ;单保慈
刊名NEUROSCIENCE BULLETIN
2012
卷号28期号:5页码:541-549
关键词functional magnetic resonance imaging post-traumatic stress disorder regional homogeneity resting-state
学科分类Neurosciences & Neurology
DOI10.1007/s12264-012-1261-3
英文摘要Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
收录类别SCI
WOS记录号WOS:000309357800009
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224010
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
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Yin, Y,Jin, CF,Eyler, LT,et al. Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study[J]. NEUROSCIENCE BULLETIN,2012,28(5):541-549.
APA Yin, Y.,Jin, CF.,Eyler, LT.,Jin, H.,Hu, XL.,...&Li, LJ;单保慈.(2012).Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study.NEUROSCIENCE BULLETIN,28(5),541-549.
MLA Yin, Y,et al."Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study".NEUROSCIENCE BULLETIN 28.5(2012):541-549.
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