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Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States
Wang B(汪冰); Wang, B; Zhou XY(周晓艳); Yin, JJ; Zhou, XY; Kurash, I; Chai, ZF; Zhao, YL; Feng, WY;柴之芳; Zhao YL(赵宇亮); Feng WY(丰伟悦)
刊名JOURNAL OF PHYSICAL CHEMISTRY C
2013
卷号117期号:1页码:383-392
学科分类Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1021/jp3101392
英文摘要A wide range of nanoparticles (NPs) have been found to generate free radicals in biological systems. Hence, it is hypothesized that free radical generation may play a key role in the mechanism of nanomaterial toxicity in vivo. However, the main physicochemical basis for the free radical generation particularly in the biomicroenvironment has not yet been fully established. In this study, we performed comprehensive spectroscopic techniques to probe the physicochemical origin of free radical generation induced by iron oxide nanoparticles in biomicroenvironment. We demonstrated that alpha-Fe2O3 and gamma-Fe2O3 NPs induced hydroxyl radical ((OH)-O-center dot) via homogeneous and heterogeneous Fenton process, depending on the biological microenvironment of pH and reducing agent presence. The physicochemical structures such as chemical states of oxygen and iron on nanosurface are the key factors in the homogeneous and heterogeneous catalytic reactions. A noteworthy finding was that in situ surface reduction of Fe2O3 NPs occurred in the presence of a physiological amount of biological reducing agents (L-cysteine or NADPH), which could enhance and even reverse the capacity of (OH)-O-center dot generation by alpha-Fe2O3 and gamma-Fe2O3 NPs under low pH 1.2 condition. The present study demonstrates that exploration of the physicochemical basis at the nanobio interface in biomicroenvironments may help to understand the mechanism of nanotoxicity and guide safe design of nanomaterials for biomedical application
收录类别SCI
WOS记录号WOS:000313220700051
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223965
专题院士_期刊论文
中国科学院高能物理研究所_多学科研究中心
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Wang B,Wang, B,Zhou XY,et al. Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2013,117(1):383-392.
APA 汪冰.,Wang, B.,周晓艳.,Yin, JJ.,Zhou, XY.,...&丰伟悦.(2013).Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States.JOURNAL OF PHYSICAL CHEMISTRY C,117(1),383-392.
MLA 汪冰,et al."Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States".JOURNAL OF PHYSICAL CHEMISTRY C 117.1(2013):383-392.
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