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The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces
Zhang, YL; Gao ZQ(高增强); Gao, ZQ; Guo, Z; Zhang, HP; Zhang, ZZ; Luo, M; Hou, HF; Huang, AL; Dong, YH; Wang, DQ;侯海峰; Dong YH(董宇辉)
2013
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号439期号:3页码:346-350
摘要Lipocalin alpha 1-microglobulin (alpha 1M) is a conserved glycoprotein present in plasma and in the interstitial fluids of all tissues. alpha 1M is linked to a heterogeneous yellow-brown chromophore of unknown structure, and interacts with several target proteins, including alpha 1-inhibitor-3, fibronectin, prothrombin and albumin. To date, there is little knowledge about the interaction sites between alpha 1M and its partners. Here, we report the crystal structure of the human alpha 1M. Due to the crystallization occurring in a low ionic strength solution, the unidentified chromophore with heavy electron density is observed at a hydrophobic inner tube of alpha 1M. In addition, two conserved surface regions of alpha 1M are proposed as putative protein-protein interface sites. Further study is needed to unravel the detailed information about the interaction between alpha 1M and its partners. (C) 2013 Elsevier Inc. All rights reserved.
关键词alpha 1-Microglobulin Crystal structure Homodimer Chromophore Interface
学科领域Biochemistry & Molecular Biology; Biophysics
DOI10.1016/j.bbrc.2013.08.084
收录类别SCI
WOS记录号WOS:000325448800005
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223948
专题多学科研究中心
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GB/T 7714
Zhang, YL,Gao ZQ,Gao, ZQ,et al. The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,439(3):346-350.
APA Zhang, YL.,高增强.,Gao, ZQ.,Guo, Z.,Zhang, HP.,...&董宇辉.(2013).The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,439(3),346-350.
MLA Zhang, YL,et al."The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 439.3(2013):346-350.
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