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The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease
Wang HJ(王华建); Wang M(王萌); Wang B(汪冰); Wang, HJ; Wang, M; Wang, B; Li, M; Chen, HQ; Yu, XH; Zhao, YL; Feng, WY; Chai, ZF; Li M(李明); Chen HQ(陈汉清); Zhao YL(赵宇亮); Feng WY(丰伟悦); Chai ZF(柴之芳)
刊名METALLOMICS
2012
卷号4期号:3页码:289-296
学科分类Biochemistry & Molecular Biology
DOI10.1039/c2mt00104g
英文摘要The enrichment of transition metals in the brain and the dyshomeostasis of metals are thought to be important etiological factors for elderly people in a number of neurodegenerative diseases, including Alzheimer's disease (AD). However, the understanding of how biometals dynamically dysregulate in the stages of AD development, such as the exact time-dependent and site-dependent accumulation in the brain with AD progression, is still limited. Herein, by using the APP/V717I transgenic mouse model and age-matched mice as control, we offer distinctive in situ and quantitative images of metals (Cu, Fe, Zn and Ca) in brain sections by synchrotron radiation micro beam X-ray fluorescence (SR-mu XRF). The images show that Fe and Ca increased with brain aging in both AD and control (CNT) mice, and Cu, Fe, Zn and Ca appeared significantly elevated in AD mice and showed an obvious age-dependent rise. Fe, Cu and Zn were obviously specifically enriched in the cortex and hippocampus, which were also the plaque-formation sensitive brain regions. Our results demonstrate that the enrichment of transition metals with age and metals' dyshomeostasis in specific regions may contribute together to the etiology and development of AD in elderly people. The XANES measurements of Cu and Fe show evidence that Cu may have redox properties in the AD brain.
收录类别SCI
WOS记录号WOS:000300886700008
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223928
专题院士_期刊论文
中国科学院高能物理研究所_粒子天体物理中心
中国科学院高能物理研究所_多学科研究中心
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Wang HJ,Wang M,Wang B,et al. The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease[J]. METALLOMICS,2012,4(3):289-296.
APA 王华建.,王萌.,汪冰.,Wang, HJ.,Wang, M.,...&柴之芳.(2012).The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease.METALLOMICS,4(3),289-296.
MLA 王华建,et al."The distribution profile and oxidation states of biometals in APP transgenic mouse brain: dyshomeostasis with age and as a function of the development of Alzheimer's disease".METALLOMICS 4.3(2012):289-296.
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