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Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli
He X(何潇); He, X; Li YY(李媛媛); Kuang, YS; Li, YY; Zhang, HF; Ma, YH; Bai, W; Zhang, ZY; Wu, ZQ; Zhao, YL; Chai, ZF;; Zhang HF(张海峰); Ma YH(马宇辉); Bai W(白伟); Zhang ZY(张智勇); Zhao YL(赵宇亮); Chai ZF(柴之芳)
2012
Source PublicationNANOTOXICOLOGY
Volume6Issue:3Pages:233-240
AbstractCeria nanoparticles have attracted a great deal of concern about their impact on human health and the environment due to their widespread applications. In the present work, different exposure media (normal saline and phosphate-buffered saline [PBS]) were used to adjust the surface charge density in order to investigate the influence of surface charge on the cytotoxicity of ceria nanoparticles for Escherichia coli. The results showed that the direct contact mediated by the electrostatic attraction between the cell wall and the positive-charged ceria nanoparticles in normal saline would result in outer membrane destabilization, increased reactive oxygen species (ROS) production and loss of viability. The situation in PBS was totally different, with significantly reduced contacts, so no outer membrane destabilization, no increased ROS production, and no cytotoxicity. The results suggested that surface charge density was closely involved in the cytotoxicity of ceria nanoparticles for E. coli. This work as a well designed comparison study contributes to a better understanding of the charge-associated biological effects of nanomaterials.
KeywordCeria nanoparticles cytotoxicity exposure media surface charge density in situ assessment
Subject AreaScience & Technology - Other Topics; Toxicology
DOI10.3109/17435390.2011.569097
Indexed BySCI
WOS IDWOS:000302560400001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/223901
Collection院士
多学科研究中心
Recommended Citation
GB/T 7714
He X,He, X,Li YY,et al. Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli[J]. NANOTOXICOLOGY,2012,6(3):233-240.
APA 何潇.,He, X.,李媛媛.,Kuang, YS.,Li, YY.,...&柴之芳.(2012).Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli.NANOTOXICOLOGY,6(3),233-240.
MLA 何潇,et al."Changing exposure media can reverse the cytotoxicity of ceria nanoparticles for Escherichia coli".NANOTOXICOLOGY 6.3(2012):233-240.
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