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Metallofullerol nanoparticles with low toxicity inhibit tumor growth by induction of G0/G1 arrest (Retracted article. See vol. 8, pg. 1356, 2013)
Meng, J; Xing, JM; Ma, XW; Cao, WP; Lu, J; Wang, YZ; Gao, XY; Sun, BY; Liang, XJ; Zhao, YL;高学云; Sun BY(孙宝云); Zhao YL(赵宇亮)
2013
发表期刊NANOMEDICINE
卷号8期号:2页码:203-213
摘要Aims: [Gd@C-82(OH)(22)](n) is a new type of nanoparticle with potent antineoplastic activity and low toxicity compared with traditional drugs. In this study, we explored, for the first time, the effect of [Gd@C-82(OH)(22)](n) on the cell cycle using human breast cancer MCF-7 and human umbilical vein endothelial ECV304 cell lines by flow cytometry. Methods: Cell viability was assessed through CCK-8 assay, and MCF-7 tumor-bearing mice were examined after 2 weeks of treatment with [Gd@C-82(OH)(22)](n). Cell cycle-related gene expression was detected by microarray and confirmed by real-time PCR and RNAi. Results: Cell viability studies confirmed that [Gd@C-82(OH)(22)](n) inhibits breast cancer effectively with very low toxicity. Flow cytometric data and microarray results reveal that [Gd@C-82(OH)(22)](n) mediates G0/G1 arrest in both cell lines by regulating the expression of several genes, such as cyclin D2, cyclin E and CDK4, among others, in the related cell cycle. Conclusion: Results further demonstrated that [Gd@C-82(OH)(22)](n) could inhibit tumor growth by inducing tumor cell and vein endothelial cell G0/G1 arrest, which may explain the low toxicity of [Gd@C-82(OH)(22)](n).
关键词cell cycle G0/G1 arrest metallofullerene nanomedicine nanoparticle
学科领域Biotechnology & Applied Microbiology; Science & Technology - Other Topics
DOI10.2217/NNM.12.95
收录类别SCI
WOS记录号WOS:000314791200015
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223891
专题多学科研究中心
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Meng, J,Xing, JM,Ma, XW,et al. Metallofullerol nanoparticles with low toxicity inhibit tumor growth by induction of G0/G1 arrest (Retracted article. See vol. 8, pg. 1356, 2013)[J]. NANOMEDICINE,2013,8(2):203-213.
APA Meng, J.,Xing, JM.,Ma, XW.,Cao, WP.,Lu, J.,...&赵宇亮.(2013).Metallofullerol nanoparticles with low toxicity inhibit tumor growth by induction of G0/G1 arrest (Retracted article. See vol. 8, pg. 1356, 2013).NANOMEDICINE,8(2),203-213.
MLA Meng, J,et al."Metallofullerol nanoparticles with low toxicity inhibit tumor growth by induction of G0/G1 arrest (Retracted article. See vol. 8, pg. 1356, 2013)".NANOMEDICINE 8.2(2013):203-213.
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