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White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder
Zhang, Y; Li, LJ; Yu, RJ; Liu, J; Tang, JS; Tan, LW; Liao, M; Yang, F; Shan, BC;单保慈
2013
发表期刊JOURNAL OF AFFECTIVE DISORDERS
卷号148期号:2-3页码:196-201
摘要Background: Several neurobiological models of anxiety disorder posit a primary role for dysfunction of the amygdala and anterior cingulate cortex (ACC). This study tests the hypothesis that patients with generalized anxiety disorder (GAD) have abnormal white matter microstructure in the amygdala and ACC, as inferred from diffusion tensor imaging, compared with healthy controls. Methods: Subjects were 16 right-handed, first-episode, treatment-naive GAD patients without comorbid disorders and 26 matched, healthy comparison controls. All subjects underwent diffusion tensor imaging and structural magnetic resonance imaging brain scanning. Fractional anisotropy (FA), a robust intravoxel measure of water self-diffusion, was compared between groups on a voxel-by-voxel basis. Associations between clinical ratings of symptom severity (i.e., the Hamilton Anxiety Scale and the Penn State Worry Questionnaire) and FA were assessed. Results: Compared with healthy volunteers, patients demonstrated significantly higher FA in the right amygdala white matter and lower FA in the caudal ACC/mid-cingulate cortex white matter. Higher right amygdala FA correlated significantly with higher Hamilton Anxiety Scale scores and higher Penn State Worry Questionnaire scores. Limitations: The sample size was modest and may contribute to false positive effects. Conclusions: These findings provide the first evidence of an abnormality in white matter microstructure that involves the amygdala and the cingulate cortex in the pathogenesis of GAD, and are consistent with neurobiological models that posit a defect in emotion-related brain regions. (c) 2012 Elsevier B.V. All rights reserved.
关键词Amygdala Anterior cingulate cortex Generalized anxiety disorder Diffusion tensor imaging Magnetic resonance imaging
学科领域Neurosciences & Neurology; Psychiatry
DOI10.1016/j.jad.2012.11.060
收录类别SCI
WOS记录号WOS:000318909700006
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223890
专题核技术应用研究中心
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Zhang, Y,Li, LJ,Yu, RJ,et al. White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2013,148(2-3):196-201.
APA Zhang, Y.,Li, LJ.,Yu, RJ.,Liu, J.,Tang, JS.,...&Shan, BC;单保慈.(2013).White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder.JOURNAL OF AFFECTIVE DISORDERS,148(2-3),196-201.
MLA Zhang, Y,et al."White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder".JOURNAL OF AFFECTIVE DISORDERS 148.2-3(2013):196-201.
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