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Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells
Meng H(孟幻); Xing GM(邢更妹); Meng, H; Xing, GM; Blanco, E; Song, Y; Zhao, LN; Sun, BY; Li, XD; Wang, PC; Korotcov, A; Li, W; Liang, XJ; Chen, CY; Yuan, H; Zhao, F; Chen, Z; Sun, T; Chai, ZF; Ferrari, M; Zhao, YL;; Song Y(宋炎); Zhao LN(赵丽娜); Sun BY(孙宝云); 李炜(多); Chen CY(陈春英); Yuan H(袁慧); Zhao F(赵峰); Chen Z(陈真); Chai ZF(柴之芳); Zhao YL(赵宇亮)
2012
发表期刊NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷号8期号:2页码:136-146
摘要The purpose of this work is to study the antimetastasis activity of gadolinium metallofullerenol nanoparticles (f-NPs) in malignant and invasive human breast cancer models. We demonstrated that f-NPs inhibited the production of matrix metalloproteinase (MMP) enzymes and further interfered with the invasiveness of cancer cells in tissue culture condition. In the tissue invasion animal model, the invasive primary tumor treated with f-NPs showed significantly less metastasis to the ectopic site along with the decreased MMP expression. In the same animal model, we observed the formation of a fibrous cage that may serve as a physical barrier capable of cancer tissue encapsulation that cuts the communication between cancer-and tumor-associated macrophages, which produce MMP enzymes. In another animal model, the blood transfer model, f-NPs potently suppressed the establishment of tumor foci in lung. Based on these data, we conclude that f-NPs have antimetastasis effects and speculate that utilization of f-NPs may provide a new strategy for the treatment of tumor metastasis. From the Clinical Editor: In this study utilizing metallofullerenol nanoparticles, the authors demonstrate antimetastasis effects and speculate that utilization of these nanoparticles may provide a new strategy in metastatic tumor therapy. (C) 2012 Elsevier Inc. All rights reserved.
关键词Nanomedicine Metallofullerenol nanoparticles Cancer metastasis Matrix metalloproteinase Fibrous cage
学科领域Science & Technology - Other Topics; Research & Experimental Medicine
DOI10.1016/j.nano.2011.08.019
收录类别SCI
WOS记录号WOS:000299316900002
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223861
专题院士
多学科研究中心
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GB/T 7714
Meng H,Xing GM,Meng, H,et al. Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2012,8(2):136-146.
APA 孟幻.,邢更妹.,Meng, H.,Xing, GM.,Blanco, E.,...&赵宇亮.(2012).Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,8(2),136-146.
MLA 孟幻,et al."Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 8.2(2012):136-146.
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