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The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery
Yan L(晏亮); Chang YN(常亚南); Zhao LN(赵丽娜); Yan, L; Chang, YN; Zhao, LN; Gu, ZJ; Liu, XX; Tian, G; Zhou, LJ; Ren, WL; Jin, S; Yin, WY; Chang, HQ; Xing, GM; Gao, XF; Zhao, YL;; Gu ZJ(谷战军); Liu XX(刘潇潇); Tian G(田甘); Zhou LJ(周亮军); Ren WL(任文璐); Jin S(金珊); Yin WY(尹文艳); Xing GM(邢更妹); Gao XF(高兴发); Zhao YL(赵宇亮)
2013
Source PublicationCARBON
ISSN0008-6223
EISSN1873-3891
Volume57Pages:120-129
AbstractIn order to produce water-dispersible nanocrystals, including upconversion nanoparticles (UCNPs) which are the new generation fluorophores and magnetic nanoparticles (Fe3O4), a polyethylenimine-modified graphene oxide (PEI-GO) was used as a nanocarrier of nanocrystals, and PEI-GO-nanocrystal hybrids were prepared by transferring hydrophobic nanocrystals from an organic phase to water. Nanocrystals were anchored onto the hydrophobic plane of PEI-GO, which was confirmed by atomic force microscopy and electron microscopy. Molecular dynamics simulation further showed that hydrophobic interaction between PEI-GO and oleic acid molecules coated on the surface of the nanocrystals was the major driving force in the transfer process. The resulting hybrids had high stability in both water and physiological solutions, and combined the functionalities of the nanocrystals and PEI-GO, such as luminescence, superparamagnetism and drug delivery capability. Through pi-pi stacking interaction between PEI-GO-UCNP and an aromatic drug, PEI-GO-UCNP was able to load a water-insoluble anticancer drug, doxorubicin (DOX), with a superior loading capacity of 100 wt.%. In addition, PEI-GO-UCNP did not exhibit toxicity on the human endothelial cells and PEI-GO-UCNP-DOX showed a high potency of killing cancer cells in vitro. (C) 2013 Elsevier Ltd. All rights reserved.
Subject AreaChemistry; Materials Science
DOI10.1016/j.carbon.2013.01.042
Indexed BySCI
Language英语
WOS IDWOS:000319030000013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/223855
Collection多学科研究中心
Recommended Citation
GB/T 7714
Yan L,Chang YN,Zhao LN,et al. The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery[J]. CARBON,2013,57:120-129.
APA 晏亮.,常亚南.,赵丽娜.,Yan, L.,Chang, YN.,...&赵宇亮.(2013).The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery.CARBON,57,120-129.
MLA 晏亮,et al."The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery".CARBON 57(2013):120-129.
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