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Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly
Dong C(董程); Hou HF(侯海峰); Dong, C; Hou, HF; Yang, X; Shen, YQ; Dong, YH; Dong YH(董宇辉)
2012
发表期刊ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
卷号68期号:2页码:95-101
摘要The outer membrane protein complex (BAM complex) plays an important role in outer membrane protein (OMP) assembly in Escherichia coli. The BAM complex includes the integral beta-barrel protein BamA as well as four lipoproteins: BamB, BamC, BamD and BamE. One of these lipoproteins, BamD, is similar to essential for the survival of Escherichia coli. The structure of BamD at 2.6 angstrom resolution shows that this lipoprotein is composed of ten a-helices that form five tetratricopeptide-repeat (TPR) motifs. The arrangement of the BamD motifs is similar to that in the periplasmic part of BamA. One of the ten a-helices, a10, which has been shown to be important for the similar to assembly of the BAM complex, is located in the very C-terminal region of BamD. A deep groove between TPR domains 4 and 5 is also observed. This groove, as well as the surface around a10, may provide binding sites for other components of the BAM complex. The C-terminal region of similar to BamD serves as a platform for interactions with other components of the BAM complex. The N-terminal region shares structural similarity to other proteins whose functions are related to assistance in or regulation of secretion. Therefore, this region is likely to play an important role in the insertion of other outer membrane proteins.
关键词Gram-negative bacteria BAM complex OMP POTRA domains TPR motif
学科领域Biochemistry & Molecular Biology; Biophysics; Crystallography
DOI10.1107/S0907444911051031
收录类别SCI
WOS记录号WOS:000299469100001
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223838
专题多学科研究中心
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GB/T 7714
Dong C,Hou HF,Dong, C,et al. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY,2012,68(2):95-101.
APA 董程.,侯海峰.,Dong, C.,Hou, HF.,Yang, X.,...&董宇辉.(2012).Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly.ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY,68(2),95-101.
MLA 董程,et al."Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly".ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 68.2(2012):95-101.
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