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Effects of Chronic Chromate Exposure on Human Serum Prostate Specific Antigen: A Cross Sectional Study
Wang, TC; Jia, G; Song, YS; Zhang, J; Ma, YH; Feng, WY; Leu, LZ; Zhang, N; Zhou, JW; Yan, L; Zhen, S; Qian, Q; Feng WY(丰伟悦)
2012
发表期刊INDUSTRIAL HEALTH
卷号50期号:2页码:95-102
摘要The detrimental effect of chronic chromium (Cr) exposure on the prostate has never been studied. Here, we report the prostate specific antigen (PSA) changes in occupational chromate exposed workers. In this study, eighty six male occupational chromate exposed workers and forty five age-matched controls were recruited. The concentration of Cr in urine (U-Cr), serum total PSA (tPSA), free PSA (fPSA), high sensitive C reactive protein (Hs-CRP) and peripheral white blood cells count (WBC) were measured. The results show that the U-Cr, serum tPSA, Hs-CRP and WBC were significantly higher in Cr exposed workers when compared to the controls. Contrastively, the serum fPSA level in Cr exposed workers was lower than controls. A significant positive correlation between U-Cr and serum tPSA was observed. Multiple linear regression analysis revealed that serum tPSA and fPSA level was statistically associated with the serum Hs-CRP and U-Cr concentration in Cr exposed workers. These observations suggested that chronic Cr exposure could produce potential prostate injury and the nonspecific inflammation at least might be one of the reasons to explain the elevated concentration of tPSA in chronic occupational chromate exposed workers.
关键词Chromium Chromate Prostate specific antigen C reactive protein Peripheral white blood cells count
学科领域Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology
收录类别SCI
WOS记录号WOS:000302200300005
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223837
专题多学科研究中心
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GB/T 7714
Wang, TC,Jia, G,Song, YS,et al. Effects of Chronic Chromate Exposure on Human Serum Prostate Specific Antigen: A Cross Sectional Study[J]. INDUSTRIAL HEALTH,2012,50(2):95-102.
APA Wang, TC.,Jia, G.,Song, YS.,Zhang, J.,Ma, YH.,...&丰伟悦.(2012).Effects of Chronic Chromate Exposure on Human Serum Prostate Specific Antigen: A Cross Sectional Study.INDUSTRIAL HEALTH,50(2),95-102.
MLA Wang, TC,et al."Effects of Chronic Chromate Exposure on Human Serum Prostate Specific Antigen: A Cross Sectional Study".INDUSTRIAL HEALTH 50.2(2012):95-102.
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