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The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population
Wei, QL; Diao, FC; Kang, Z; Gan, ZY; Han, ZL; Zheng, LR; Li, LJ; Guo, XF; Shan, BC; Liu, CL; Zhao, JP; Zhang, JB; Dan BC(单保慈)
2012
发表期刊NEUROSCIENCE LETTERS
卷号517期号:1页码:21-24
摘要Schizophrenia is thought to arise in part from abnormal gray matter (GM), which are partly shared by the relatives of the probands. DISC1 is one of the most promising susceptibility genes of schizophrenia and a SNP rs821597 (A) in the gene was associated with schizophrenia in Han Chinese population. In this study, 61 healthy controls and 72 with schizophrenic patients were genotyped at rs821597, and underwent T1-weighted MRI for the density of GM. The results showed that the risk allele (A) carriers had higher GM density in regional left parahippocampal gyrus and right orbitofrontal cortex in schizophrenic patients, but had reduced GM density of these brain regions in healthy controls. The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
关键词DISC1 Schizophrenia Gray matter Magnetic resonance imaging
学科领域Neurosciences & Neurology
DOI10.1016/j.neulet.2012.03.098
收录类别SCI
WOS记录号WOS:000304642500005
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223765
专题核技术应用研究中心
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GB/T 7714
Wei, QL,Diao, FC,Kang, Z,et al. The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population[J]. NEUROSCIENCE LETTERS,2012,517(1):21-24.
APA Wei, QL.,Diao, FC.,Kang, Z.,Gan, ZY.,Han, ZL.,...&单保慈.(2012).The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.NEUROSCIENCE LETTERS,517(1),21-24.
MLA Wei, QL,et al."The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population".NEUROSCIENCE LETTERS 517.1(2012):21-24.
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