The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging
杨文江;Yang, WJ; Zhao, ZQ; Fang, W; Zhang, XZ
刊名APPLIED RADIATION AND ISOTOPES
2013
卷号74页码:1-5
关键词DTPA-LSA Tc-99m ASGP Instant lyophilized kit SPECT imaging
学科分类Chemistry; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging
DOI10.1016/j.apradiso.2012.12.009
英文摘要Diethylenetriaminepentaacetic acid neolactosyl human serum albumin (DTPA-LSA) was prepared and labeled with technetium-99m. The labeling conditions of Tc-99m-DTPA-LSA were optimized, and lyophilized kit was developed for instant preparing of Tc-99m-DTPA-LSA. Tc-99m-DTPA-LSA showed high liver uptake in normal mice (> 96% ID/g at 5 min after injection), and it could be blocked significantly by pre-injecting free neogalactosylalbumin (NGA). Single photon emission computed tomography (SPECT) study was performed in normal Japanese White rabbits and SPECT images with high quality were obtained at 15, 30, 60, and 120 min after injection of the radiotracer. The promising biological properties of Tc-99m-DTPA-LSA combined with the development of reliable and instant lyophilized DTPA-LSA kit afford the opportunity of hepatic receptor imaging for routine clinical assessment of hepatic function. (c) 2012 Elsevier Ltd. All rights reserved.
收录类别SCI
WOS记录号WOS:000316978400001
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223754
专题中国科学院高能物理研究所_核技术应用研究中心_期刊论文
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杨文江;Yang, WJ,Zhao, ZQ,Fang, W,et al. The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging[J]. APPLIED RADIATION AND ISOTOPES,2013,74:1-5.
APA 杨文江;Yang, WJ,Zhao, ZQ,Fang, W,&Zhang, XZ.(2013).The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging.APPLIED RADIATION AND ISOTOPES,74,1-5.
MLA 杨文江;Yang, WJ,et al."The preparation of Tc-99m-DTPA-LSA and its instant lyophilized kit for hepatic receptor imaging".APPLIED RADIATION AND ISOTOPES 74(2013):1-5.
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