IHEP OpenIR  > 院士
Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis
CHEN,Zhongcai; CAI,Shang; JIANG,Qing; ZHANG,Chuanmao; Tang,Xiaowei; Tang XW(唐孝威)
2005
发表期刊科学通报(英文版)
期号3页码:229-235
摘要Microtubule and microfilament cytoskeletons play key roles in the whole process of cytokinesis. Although a number of hypotheses have been proposed to elucidate the mechanism of cytokinesis by microtubule and actin filament cytoskeletons, many reports are conflicting. In our study, combining the cytoskeletons drug treatments with the time-lapse video technology, we retested the key roles of microtubule and actin filament in cytokinesis. The results showed that depolymerization of microtubules by Nocodazole after the initiation of furrowing would not inhibit the furrow ingression, but obviously decrease the stiffness of daughter cells. Depolymerizing actin filaments by Cytochalasin B before metaphase would inhibit the initiation of furrowing but not chromosome segregation, resulting in the formation of binucleate cells; however, depolymerizing actin filaments during anaphase would prevent furrowing and lead to the regress of established furrow, also resulting in the formation of binucleate cells. Further, depolymerizing microtubules and actin filaments simultaneously after metaphase would cause the quick regress of the furrow and the formation of binucleate cells. From these results we propose that a successful cytokinesis requires functions and coordination of both the microtubule and actin filament cytoskeletons. Microtubule cytoskeleton may function in the positioning and initiation of cleavage furrow, and the actin filament cytoskeleton may play key roles in the initiation and ingression of the furrow.
关键词cytokinesis microtubule actin Filament cytochalasin B nocodazole
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/215772
专题院士
粒子天体物理中心
推荐引用方式
GB/T 7714
CHEN,Zhongcai,CAI,Shang,JIANG,Qing,et al. Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis[J]. 科学通报(英文版),2005(3):229-235.
APA CHEN,Zhongcai,CAI,Shang,JIANG,Qing,ZHANG,Chuanmao,Tang,Xiaowei,&唐孝威.(2005).Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis.科学通报(英文版)(3),229-235.
MLA CHEN,Zhongcai,et al."Roles for microtubule and microfilament cytoskeletons in animal cell cytokinesis".科学通报(英文版) .3(2005):229-235.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
9477.pdf(3120KB)期刊论文作者接受稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[CHEN,Zhongcai]的文章
[CAI,Shang]的文章
[JIANG,Qing]的文章
百度学术
百度学术中相似的文章
[CHEN,Zhongcai]的文章
[CAI,Shang]的文章
[JIANG,Qing]的文章
必应学术
必应学术中相似的文章
[CHEN,Zhongcai]的文章
[CAI,Shang]的文章
[JIANG,Qing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。