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A template of rat brain based on fMRI T2* imaging
HU,Zhenghui; Wu YG(吴义根); Wang,Xiaochuan; Wang,jianzhi; CHEN,Feiyan; Tang,Xiaowei; Tang XW(唐孝威)
2005
发表期刊自然科学进展(英文版)
期号6页码:502-506
摘要The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results processed with statistical parametric mapping (SPM99) software are in agreement with the results from immunohistochemical experiment, which proves that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies.
关键词fMRI animal model atlas template normalization T2*
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/214880
专题院士
粒子天体物理中心
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GB/T 7714
HU,Zhenghui,Wu YG,Wang,Xiaochuan,et al. A template of rat brain based on fMRI T2* imaging[J]. 自然科学进展(英文版),2005(6):502-506.
APA HU,Zhenghui.,吴义根.,Wang,Xiaochuan.,Wang,jianzhi.,CHEN,Feiyan.,...&唐孝威.(2005).A template of rat brain based on fMRI T2* imaging.自然科学进展(英文版)(6),502-506.
MLA HU,Zhenghui,et al."A template of rat brain based on fMRI T2* imaging".自然科学进展(英文版) .6(2005):502-506.
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